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KMID : 1140120110160020102
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Cancer Prevention Research
2011 Volume.16 No. 2 p.102 ~ p.119
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Inhibitory Activity of Compounds Originated from Marine Algae-Symbiotic Microorganisms on Epidermal Growth Factor Receptor Kinase in HeLa Human Cervix Carcinoma Cells
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Jo Mi-Jeong
Son Byeng-Wha
Kim Kun-Do
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Abstract
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Binding of ligand such as epidermal growth factor on epidermal growth factor receptor (EGFR), a member of the receptor tyrosine kinases (RTK) protein, leads to the receptor heterodimerization, phosphorylation and activation the loops in downstream. Development of the specific or broad spectrum of inhibitor for phosphorylation of EGFR is worth for cancer therapy because the EGFR plays a role as regulator in cellular processes such as proliferation, differentiation and cell survival. In this study, the effects of several compounds originated from marine algae-symbiotic microorganisms on the activity of EGFR kinase in HeLa human cervical cancer cells were investigated. The results shown the purified compounds inhibited the expression and phosphorylation of EGFR and/or EGF-related downstream molecule such as extracellular signal-regulated kinase (ERK) 1/2 in HeLa cells. It has finally decreased the growth of human cervix carcinoma cells. The results suggested that the compounds may have a therapeutic potential as inhibitors for EGFR to treat EGFR mediated diseases.
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KEYWORD
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Receptor tyrosine kinase (RTK), Marine algae, Symbiotic microorganism, ERK1/2, HeLa
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